Harnessing this principle, we have developed a novel protein scaffold, a repeating peptide array termed SunTag, which can recruit multiple copies of an antibody-fusion protein. We show that the SunTag …

Mar 18, 2025 · This study presents a novel, modular prime-editing system, SunTag-PE, that achieves gene editing levels comparable to larger, fused systems, but can be efficiently delivered into cells …

Mar 28, 2017 · In developing their SunTag technology, the Vale and Weissman labs took this biological lesson and created a system to amplify fluorescent signals. Named for the "stellar explosion …

Mar 27, 2025 · ABSTRACT The ability to quantitatively study mRNA translation using SunTag imaging is transforming our understanding of the translation process. Here, we expand the SunTag method to …

Oct 23, 2014 · A protein tagging system, SunTag, is developed to enable long-term single-molecule imaging and to enhance CRISPR-based transcriptional activation in living cells.

SunTag, SAM, and VPR have all shown significant improvements...a single copy of VP64 per each dCas9, SunTag uses a repeating peptide array to fused with multiple copies...to be recruited per …

We are employing SunTag technology to visualize gene expression control in living cells with incredible precision to uncover how regulatory mechanisms function at the molecular level, and how regulation …