Histone chaperones also participate in the selective deposition of histone variants, which are functionally distinct from canonical histones. For example, HIRA is a chaperone that …

A histone is a type of protein that plays a critical role in the structural organization and regulation of DNA within the nucleus of eukaryotic cells.

3 days ago · A histone is a protein that provides structural support for a chromosome. Each chromosome contains a long molecule of DNA, which must fit into the cell nucleus.

Aug 22, 2025 · When DNA is damaged, histone modifications can help make affected DNA regions more accessible to repair enzymes. For example, specific histone modifications can …

These complex histone modifications constitute the so-called epigenetic histone code, which might play a role in determining and stabilizing gene expression patterns from one generation …

A protein that is part of the histone family of basic proteins which associate with DNA in the nucleus and help to condense the DNA into a smaller volume.

May 4, 2025 · The histone family consists of five main classes: H1 (linker histone) and the core histones H2A, H2B, H3, and H4. Core histones form an octamer composed of two H2A-H2B …

Aberrant histone modifications can lead to altered gene expression patterns, contributing to disease progression. The recognition of histones’ pivotal role in disease has spurred the …

Histone was first discovered by Albrecht Kossel in 1884 [1]. Histones are a family of alkaline proteins found in the nuclei of eukaryotic cells and are the major structural components of …

Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.