When a cell receives a message from outside, it generates a molecule called cyclic AMP (cAMP) to relay this message. To ensure the signal reaches the correct effector without triggering pathways ...

Alzheimer's disease (AD) is a serious neurodegenerative disease largely affecting older adults. Apart from age, it also shows ...

Heterotrimeric G proteins, comprising Gα, Gβ and Gγ subunits, are central to the transduction of extracellular signals into precise intracellular responses in plants. These proteins not only regulate ...

Learn more about the “glue sniffer” protein, which is able to detect brain cells’ incoming chemical signals, and what that ...

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are ...

Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in ...

Gastric cancer cells can activate KRAS-driven signals, enabling autonomous tumor growth by producing their own WNT proteins. New research reveals how gastric cancer cells exploit WNT signaling for ...

The startup is developing a medicine that can very specifically degrade cancerous forms of EGFR, the target of an array of ...