Gene therapy ‘switch’ may offer non-addictive pain relief. New approach targets pain signals while leaving the rest of the brain untouched.

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...

Pea-size clusters of human cells called brain organoids inspire both hope and fear. Experts are debating how scientists can ...

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate ...

Scientists created a model of the human pain pathway in a dish by connecting four separate brain organoids. The feat should help them understand sensory disorders like those affecting pain perception.

New research into the mechanism of the placebo effect sheds light on the brain circuitry involved in pain relief. The study, conducted by scientists at the University of North Carolina (UNC), Stanford ...

UNC School of Medicine research reveals a pain control pathway from the cortex to cerebellum crucial for placebo analgesia – when the expectation of pain relief leads to pain alleviation without a ...

Four tiny 3D organs connected themselves in a lab dish, forming a replica of the human pain pathway, in a new study. The discovery allows scientists to better understand chronic pain and how pain ...

Salk scientists uncover a key neural circuit in mice that gives pain its emotional punch, opening new doors for treating fibromyalgia, migraine, and PTSD LA JOLLA (July 9, 2025)—Pain isn’t just a ...

René Descartes gave a colorful description of the mechanism of pain in the 17th Century: "Particles" of fire set in motion a spot on the skin of the foot, and by means of a "delicate thread" they open ...