Infection with the pathogen Clostridium difficile is a significant source of healthcare-associated infections and estimated to account for 12 percent of all HAIs in the U.S.1 C. diff infection is the ...

This study explores the effectiveness of toxin testing in predicting Clostridioides difficile infection (CDI) outcomes, revealing that patients with negative toxin results were less likely to ...

Clostridium difficile infection is one of the most common healthcare-associated infections in adults in the United States. Older Americans are especially vulnerable to CDI, 2 and this infection has ...

The high false-negative rate of EIA for C. difficile toxin apparently reflects nothing but the variability of a poor test. A better test is urgently needed. (The PCR test used in this study is ...

Therefore, a two-step diagnostic algorithm with a rapid highly sensitive screening method to identify positive samples, to be confirmed by gold standard, should be strongly recommended. Some ...

These toxins damage the lining of the colon and can cause a significant infection. Even a short course of antibiotics may lead to a C. diff infection, especially in people with weakened immune systems ...

Affecting roughly half a million Americans each year, bacterial infections caused by Clostridioides difficile—commonly known ...

In a major step toward a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to ...

A potential first-in-class investigational microbiome therapeutic, SER-109, was safe and observed to sustain low Clostridioides difficile (C. diff) recurrence rates for adults, according to the phase ...

A new study, led by researchers from the University of California, Irvine (UCI), uncovers the long-sought-after, three-dimensional structure of a toxin primarily responsible for devastating ...

A new article details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff -- a virulent health care-associated infection that causes ...